Last week I enjoyed an innovative performance of Shakespeare’s MacBeth at the Guthrie Theater in Minneapolis. The director, Joe Dowling, takes some liberties with the original production, such as dropping the warrior MacBeth on stage down a ninja rope and equipping him with a machine gun. However, mostly the gruesome killings that riddle this dark play are accomplished with old-fashioned daggers and swords.
Being a chemical engineer who abhors overly complicated recipes, it bothers me that the three weird sisters in Macbeth put so many ingredients into their witches brew. It would be very hard to scale up their potent product from bench-level kettle to massive manufacturing. By the way, thanks to this heads-up by Nigel Beale I cracked this coven’s confidential code on components; for example, eye of newt, which cannot be easily sourced, is really readily-available mustard seed. Nevertheless, I’ll bet that a good mixture screening experiment, followed-up by an in-depth formulation design, such as this one on a cell-culture medium, would reveal that only a few key ingredients might do the job for enabling clairvoyance or whatever a witch might be up to.
Keep it simple, I say. Or as Shakespeare advises more eloquently, “Brevity is the soul of wit.”