Just in time for the partying hearty for Christmas today, my son-in-law Ryan, a chemist with 3M, alerted me to a statistical study published after last year’s holiday season by the The American Journal of Clinical Nutrition that questioned the advice of grape or grain but never the twain. Naturally, being a drinker of these undistilled alcoholic beverages, I wondered if my tendency to drink beer before dinner and wine for the meal would pass the test. But being a wonk for design of experiments, I was most curious to see a randomized controlled multiarm matched-triplet crossover trial—pictured below for this experiment on the order of addition for beer and/or wine.
Based on results from 90 participants, including a control group, “neither type nor order of consumed alcoholic beverages significantly affected hangover intensity (P > 0.05)”. What really mattered was the total consumption, although, interestingly, hangover intensity did not correlate to breath alcohol concentration (BrAC). However, the authors warn that
“The fact that we did not find a direct correlation between maximal BrAC and hangover intensity should not be misinterpreted as an invitation to drink until the cows come home. Likely, this correlation overall does exist but is not directly apparent in the narrow range of peak alcohol levels studied here.”
It’s disclosed at the end that Carlsberg provided the beer (premium Pilsner lager recipe from 1847) free of charge “for the sole purpose of utilization in this study”. Although I trust the author’s disclaimer of any bias, perhaps further study is warranted with stronger beers such as a Belgian trippel. Maybe wine would then be best drunk first. To be continued…